Next available departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Gateway Station | Downtown Greyhound Station | Cheapest | |||||
| Gateway Station | Chicago 95Th & Dan Ryan | Fastest | |||||
 | Gateway Station | Chicago (Union Station), IL | No tags | |||||
| Gateway Station | Downtown Greyhound Station | No tags | |||||
 | Gateway Station | 537-517 W. Jackson Blvd | No tags | |||||
FlixBus + Greyhound Lines, Inc. | Gateway Station | Chicago 95Th & Dan Ryan | No tags | |||||
| Gateway Station | Chicago (Union Station), IL | No tags | |||||
| Gateway Station | Downtown Greyhound Station | No tags |
Last refresh of the prices: Today at 1:04 PM CDT.
Compare 2 ways to go from St. Louis to Chicago
Among the sustainable travel choices, the Train stands out as a good way to reach Chicago. The journey takes about 5 hours 5 minutes and with fares starting at just CN¥204, it presents an excellent value for a comfortable ride.
Where are the popular stops in St. Louis and Chicago?
Stops in Chicago
- A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA - C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare companies
Frequently asked questions about traveling from St. Louis to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from St. Louis to Chicago?
The cheapest bus tickets from St. Louis to Chicago start from CN¥280. The average price for this route is around CN¥343. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from St. Louis to Chicago?
The average bus trip duration from St. Louis to Chicago is 7h 35m, covering a distance of 257 miles (414 km). The quickest bus can get you there in 5h 50m and is operated by FlixBus.
Which bus companies service the St. Louis to Chicago route?
Several major bus companies operate on this route with 9 buses available per day, including services from FlixBus, Greyhound, Amtrak, Burlington Trailways.
What is the earliest and latest departure time for the bus from St. Louis to Chicago?
The earliest bus departs from St. Louis to Chicago at 2:00am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from St. Louis to Chicago?
A bus trip from St. Louis to Chicago generates an estimated 10.346174999999999 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from St. Louis to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Burlington Trailways, with an average rating of 4.2 out of 5 stars based on 20 reviews.
Which bus company has the best Wi-Fi from St. Louis to Chicago?
Based on reviews on Busbud, the bus company Burlington Trailways has the best Wi-Fi rating with a score of 5.0.
Which bus company has the most timely service from St. Louis to Chicago?
According to Busbud traveler reviews, the most timely bus company on this route is Burlington Trailways, with a punctuality rating of 5.0 out of 5 stars.
Which bus company has the cleanest buses from St. Louis to Chicago?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is Burlington Trailways, with a cleanliness rating of 5.0 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Chicago was searched and found on Jun 27, 2026 with a price of CN¥286To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Chicago, as early as possible.
You can expect to pay from CN¥286 to CN¥2,069 for a bus ticket from St. Louis to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at CN¥286 which is on 2026-06-27.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
