Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Orlando Bus Station | Florence, SC | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Orlando Bus Station | Bus station | No tags | ||||
| Bus | The Florida Mall | Florence, SC | No tags |
Last refresh of the prices: Last Thursday at 11:45 AM EDT.
Compare 2 ways to go from Orlando to Florence
Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 11 hours 20 minutes, and with fares starting at just $91, it presents an excellent value for a comfortable ride.
Where are the popular stops in Orlando and Florence?
Stops in Orlando
- A
Orlando Bus Station
555 N John Young Pkwy, Orlando, FL 32805 - B
Orlando RedCoach Station
RedCoach Station, 1777 McCoy Road, Orlando, FL 32809 - C
Jet Set Express Terminal
Jet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United States - D
Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830 - E
International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA - F
Seaworld Hotels
10100 International Drive , Orlando, 32821
Stops in Florence
- A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA - B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
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Frequently asked questions about travelling from Orlando to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Orlando to Florence?
The cheapest bus tickets from Orlando to Florence start from $91. The average price for this route is around $138. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Orlando to Florence?
The average bus travel time from Orlando to Florence is 11h 20m, covering a distance of 650 km. The quickest bus can get you there in 8h 25m and is operated by FlixBus.
Which bus companies service the Orlando to Florence route?
What are the earliest and latest departure times for the bus from Orlando to Florence?
The earliest bus departs from Orlando to Florence at 4:45am. And the latest bus departs at 10:55pm.
What are the CO₂ emissions for the bus trip from Orlando to Florence?
A bus trip from Orlando to Florence generates an estimated 16.238025 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Orlando to Florence?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12853 reviews.
Which bus company has the best Wi-Fi from Orlando to Florence?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Orlando to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Orlando to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Orlando to Florence, SC, US was searched and found on Jun 29, 2026 with a price of $103To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Florence, SC, US, as early as possible.
You can expect to pay from $103 to $175 for a bus ticket from Orlando to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $103 which is on 2026-07-04.
What's the cheapest way to go from Orlando to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
