Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Prague (Main Station - parking) | Brussels North Train Station | Cheapest | ||||
| Bus | Prague (Central Bus Station Florenc) | Brussels North Train Station | Fastest | ||||
| Bus | Prague (Central Bus Station Florenc) | Brussels Airport BRU (Parking P14) | No tags | ||||
| Bus | Prague (Central Bus Station Florenc) | Brussels Airport BRU (Parking P14) | No tags | ||||
| Bus | Prague (Central Bus Station Florenc) | Brussels Airport BRU (Parking P14) | No tags | ||||
| Bus | Prague (Central Bus Station Florenc) | Brussels Airport BRU (Parking P14) | No tags | ||||
| Bus | Prague (Central Bus Station Florenc) | Brussels Airport BRU (Parking P14) | No tags | ||||
| Bus | Prague (Main Railway Station) | Brussels Airport BRU (Parking P14) | No tags |
Last refresh of the prices: Yesterday at 8:52 PM CEST.
Compare 2 ways to go from Prague to Brussels
Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 17 hours 55 minutes, and with fares starting at just CLP 42,064, it presents an excellent value for a comfortable ride.
Bus stations and stops in Prague and Brussels
Stops in Prague
- A
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - B
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - C
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - D
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - E
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium - C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
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Frequently asked questions about travelling from Prague to Brussels by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Prague to Brussels?
The cheapest bus tickets from Prague to Brussels start from CLP 42,064. The average price for this route is around CLP 91,766. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Brussels?
The average bus travel time from Prague to Brussels is 17h 55m, covering a distance of 713 km. The quickest bus can get you there in 12h and is operated by RegioJet.
Which bus companies service the Prague to Brussels route?
Several major bus companies operate on this route with 37 buses available per day, including services from FlixBus, RegioJet, BlaBlaCar Bus.
What are the earliest and latest departure times for the bus from Prague to Brussels?
The earliest bus departs from Prague to Brussels at 12:10am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Prague to Brussels?
A bus trip from Prague to Brussels generates an estimated 17.817 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Prague to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1103 reviews.
Which bus company has the best Wi-Fi from Prague to Brussels?
Based on Busbud reviews, the bus company RegioJet has the highest Wi-Fi rating with a score of 3.8.
Which bus company has the best on-time performance from Prague to Brussels?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 4.1 out of 5 stars.
Which bus company has the cleanest buses from Prague to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Brussels was searched and found on Aug 26, 2026 with a price of CLP 55,468To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.
You can expect to pay from CLP 55,468 to CLP 175,912 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at CLP 55,468 which is on 2026-08-26.
