Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Siena Train Station | Milan (San Donato M3) | Cheapest | ||||
| Bus | Siena Train Station | Milan (San Donato M3) | Fastest | ||||
 | Bus | Siena Train Station | Lampugnano | No tags | ||||
| Bus | Siena Train Station | Milan (Malpensa Airport Terminal 1) | No tags | ||||
| Bus | Siena Train Station | Lampugnano | No tags | ||||
| Bus | Siena Train Station | Milan (Malpensa Airport Terminal 1) | No tags | ||||
| Bus | Siena Train Station | Lampugnano | No tags | ||||
| Bus | Siena Train Station | Milan (Malpensa Airport Terminal 1) | No tags |
Last refresh of the prices: Yesterday at 11:58 PM CEST.
Get from Siena to Milano
The journey takes about 6 hours 30 minutes, and with fares starting at just ZAR 159, it presents an excellent value for a comfortable ride.
Bus stations and stops in Siena and Milano
Stops in Siena
- A
Piazza Gramsci
Piazza Antonio Gramsci, 53100 Siena SI, Italy - B
Via Sallustio Bandini, 21
Via Sallustio Bandini, 21, 53100 Siena SI, Italy - C
Via Giuseppe Mazzini, 58
Via Giuseppe Mazzini, 58, 53100 Siena SI, Italy - D
Via Riccardo Lombardi, 42
Via Riccardo Lombardi, 42, 53100 Siena SI, Italy - E
Torre Fiorentina
Torre Fiorentina, 53100 Siena SI, Italy - F
Siena Zona Industriale
Siena FS, 53100 Siena SI, Italy
Stops in Milano
- A
Lampugnano
Via Giulio Natta, 228, 20151 Milano, Italy - B
Piazza I Maggio, 1
Piazza I Maggio, 1, 20099 Sesto San Giovanni MI, Italy - E
Milan San Donato Bus Station
Via Giuseppe Impastato, 27, 20138 Milano, Italy - F
Molino Dorino
Molino Dorino, 20151 Milano, Italy
Compare bus companies
Frequently asked questions about travelling from Siena to Milano by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Siena to Milano?
The cheapest bus tickets from Siena to Milano start from ZAR 159. The average price for this route is around ZAR 542. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Siena to Milano?
The average bus travel time from Siena to Milano is 6h 30m, covering a distance of 300 km. The quickest bus can get you there in 4h 30m and is operated by FlixBus.
Which bus companies service the Siena to Milano route?
What are the earliest and latest departure times for the bus from Siena to Milano?
The earliest bus departs from Siena to Milano at 12:45am. And the latest bus departs at 8:25pm.
What are the CO₂ emissions for the bus trip from Siena to Milano?
A bus trip from Siena to Milano generates an estimated 7.482200000000001 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Siena to Milano?
According to Busbud customers, the highest-rated bus company on this route is Itabus, with an average rating of 3.8 out of 5 stars based on 1047 reviews.
Which bus company has the best Wi-Fi from Siena to Milano?
Based on Busbud reviews, the bus company Itabus has the highest Wi-Fi rating with a score of 2.9.
Which bus company has the best on-time performance from Siena to Milano?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Siena to Milano?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Itabus, with a cleanliness rating of 4.2 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Siena to Milano was searched and found on Aug 19, 2026 with a price of ZAR 255To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Siena to Milano, as early as possible.
You can expect to pay from ZAR 255 to ZAR 1,706 for a bus ticket from Siena to Milano based on the last 2 days. You can expect to find the cheapest price for the trip at ZAR 255 which is on 2026-08-19.
