Next available departures

Next departures from Rome to Isernia on 24 September
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Wi‑Fi Toilet Power outlets	14:50	Rome Tiburtina Bus Station	2h 25m	17:15	Isernia	Cheapest
Wi‑Fi Toilet Power outlets	09:07	Termini	2h 8m	11:15	Isernia	Fastest
Wi‑Fi Toilet Power outlets	16:07	Termini	3h 13m	19:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	08:50	Rome Fiumicino Airport	9h 30m	18:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	17:20	Termini	2h 32m	19:52	Isernia	No tags

Next departures from Rome to Isernia on 25 September
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Wi‑Fi Toilet Power outlets	09:07	Termini	2h 8m	11:15	Isernia	CheapestFastest
Wi‑Fi Toilet Power outlets	16:07	Termini	3h 13m	19:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	08:50	Rome Fiumicino Airport	9h 30m	18:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	17:20	Termini	2h 32m	19:52	Isernia	No tags
Wi‑Fi Toilet Power outlets	14:50	Rome Tiburtina Bus Station	2h 25m	17:15	Isernia	No tags

Next departures from Rome to Isernia on 26 September
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Wi‑Fi Toilet Power outlets	14:50	Rome Tiburtina Bus Station	2h 25m	17:15	Isernia	Cheapest
Wi‑Fi Toilet Power outlets	09:07	Termini	2h 8m	11:15	Isernia	Fastest
Wi‑Fi Toilet Power outlets	15:42	Termini	3h 38m	19:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	04:05	Rome Fiumicino Airport	7h 30m	11:35	Isernia	No tags
Wi‑Fi Toilet Power outlets	17:20	Termini	2h 32m	19:52	Isernia	No tags
Wi‑Fi Toilet Power outlets	08:50	Rome Fiumicino Airport	9h 30m	18:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	04:40	Aeroporto Ciampino Airport (CIA)	6h 55m	11:35	Isernia	No tags

Next departures from Rome to Isernia on 27 September
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Wi‑Fi Toilet Power outlets	14:50	Rome Tiburtina Bus Station	2h 25m	17:15	Isernia	Cheapest
Wi‑Fi Toilet Power outlets	09:07	Termini	2h 8m	11:15	Isernia	Fastest
Wi‑Fi Toilet Power outlets	15:42	Termini	3h 38m	19:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	04:05	Rome Fiumicino Airport	7h 30m	11:35	Isernia	No tags
Wi‑Fi Toilet Power outlets	17:40	Termini	2h 15m	19:55	Isernia	No tags
Wi‑Fi Toilet Power outlets	08:50	Rome Fiumicino Airport	9h 30m	18:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	04:40	Aeroporto Ciampino Airport (CIA)	6h 55m	11:35	Isernia	No tags

Next departures from Rome to Isernia on 28 September
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Wi‑Fi Toilet Power outlets	14:50	Rome Tiburtina Bus Station	2h 25m	17:15	Isernia	Cheapest
Wi‑Fi Toilet Power outlets	09:07	Termini	2h 8m	11:15	Isernia	Fastest
Wi‑Fi Toilet Power outlets	04:05	Rome Fiumicino Airport	7h 30m	11:35	Isernia	No tags
Wi‑Fi Toilet Power outlets	08:50	Rome Fiumicino Airport	9h 30m	18:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	04:40	Aeroporto Ciampino Airport (CIA)	6h 55m	11:35	Isernia	No tags

Next departures from Rome to Isernia on 29 September
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Wi‑Fi Toilet Power outlets	14:50	Rome Tiburtina Bus Station	2h 25m	17:15	Isernia	Cheapest
Wi‑Fi Toilet Power outlets	09:07	Termini	2h 8m	11:15	Isernia	Fastest
Wi‑Fi Toilet Power outlets	16:07	Termini	3h 13m	19:20	Isernia	No tags
Wi‑Fi Toilet Power outlets	04:05	Rome Fiumicino Airport	7h 30m	11:35	Isernia	No tags
Wi‑Fi Toilet Power outlets	17:20	Termini	2h 32m	19:52	Isernia	No tags
Wi‑Fi Toilet Power outlets	04:40	Aeroporto Ciampino Airport (CIA)	6h 55m	11:35	Isernia	No tags

Last refresh of the prices: Today at 21:44 CEST.

Compare 2 ways to travel from Rome to Isernia

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Isernia. The journey takes about 2 hours 32 minutes and with fares starting at just CLP 18,455, it presents an excellent value for a comfortable ride.

3train per day

2h 32mAverage duration

92 milesDistance

4kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average priceCLP 14,782 - CLP 63,966	Average duration7h 4m	CO₂ emissions 4kg CO₂e
Train	Average priceCLP 18,455 - CLP 22,069	Average duration2h 32m	CO₂ emissions 4kg CO₂e

Bus stations and stops in Rome and Isernia

Stops in Rome

A
Termini
Piazza dei Cinquecento 1, 00185 Roma RM, Italy
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B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy
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C
Rome Fiumicino Airport (FCO), Train station
Fiumicino Aeroporto, 00054 Fiumicino RM, Italy
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D
Roma S. Pietro
Roma S.Pietro, 00165 Roma RM, Italy
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E
Rome Ciampino Airport
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F
Roma Trastevere
Roma Trastevere Railway Station, 00152 Roma RM, Italy
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Stops in Isernia

A
Isernia
Piazza della Repubblica, 9, 86170 Isernia IS, Italy
Visit page

Compare companies

FlixBus

3.5/515,856 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

Trenitalia

3.9/571 reviews

Staff4.5

Timeliness4.5

Cleanliness4.8

Wi‑Fi2.9

Companies in IT:FlixBus, Trenitalia, BlaBlaCar Bus, Deutsche Bahn, ALSA, FlixTrain, Rede Expressos, RegioJet, Trenitalia, NS Nederlandse Spoorwegen, Deutsche Bahn, Deutsche Bahn Regio, Sindbad, Italo

Frequently asked questions about travelling from Rome to Isernia by bus or train

Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

How much does a ticket from Rome to Isernia cost?
The cheapest tickets from Rome to Isernia start from CLP 14,782. The average price for this route is around CLP 28,784. Busbud recommends that you book your tickets in advance for a better chance of getting the lowest possible price.
How long is the journey from Rome to Isernia?
The average trip duration from Rome to Isernia is 4h 48m, covering a distance of 94 miles. The quickest vehicle can get you there in 2h 5m and is operated by Trenitalia.
Which companies operate the Rome to Isernia route?
Several major companies operate on this route with 3 trips available per day, including services from FlixBus, Trenitalia.
What are the earliest and latest departure times from Rome to Isernia?
The earliest service departs from Rome for Isernia at 04:05. And the latest service departs at 20:15.
What are the CO₂ emissions for the journey from Rome to Isernia?
A journey from Rome to Isernia produces an estimated 3.7743 kg of CO₂, making it a highly eco-friendly way to travel and a mode of transport recommended by Busbud.
Which is the best company from Rome to Isernia?
According to Busbud customers, the highest-rated company on this route is Trenitalia, with an average rating of 3.9 out of 5 stars based on 71 reviews.
Which company has the best Wi-Fi from Rome to Isernia?
According to reviews on Busbud, the company Trenitalia has the best Wi-Fi rating with a score of 2.9.
Which company offers the most punctual service from Rome to Isernia?
According to Busbud traveller reviews, the most punctual company on this route is Trenitalia, with a punctuality rating of 4.5 out of 5 stars.
Which company has the cleanest vehicles from Rome to Isernia?
According to Busbud traveller reviews, the company with the cleanest vehicles on this route is Trenitalia, with a cleanliness rating of 4.8 out of 5 stars.

Find the cheapest prices for buses and trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

21/09

CLP 14,506

22/09

CLP 13,923

Today

CLP 13,864

24/09

CLP 13,824

25/09

CLP 16,885

26/09

CLP 13,824

27/09

CLP 16,184

28/09

CLP 12,709

The cheapest trip from Rome to Isernia was searched and found on 28 Sept 2026 with a price of CLP 12,709

To save money and ensure you get the best seat, it's a good idea to buy your bus and train tickets from Rome to Isernia, as early as possible.

You can expect to pay between CLP 12,709 and CLP 52,561 for a bus or train ticket from Rome to Isernia based on the past 2 days. You can expect to find the lowest price for the trip at CLP 12,709 on 2026-09-28.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.