Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Lyon - Gerland Bus Station | Brussels-South (Gare du Midi) | Cheapest | ||||
| Bus | Lyon - Gerland Bus Station | Brussels-South (Gare du Midi) | Fastest | ||||
 | Bus
| Aéroport LYS | Brussels North Train Station | No tags | ||||
| Bus
| Aéroport LYS | Brussels North Train Station | No tags | ||||
| Bus
| Aéroport LYS | Brussels South (Gare du Midi) | No tags | ||||
| Bus
| Aéroport LYS | Brussels South (Gare du Midi) | No tags | ||||
| Bus
| Aéroport LYS | Brussels South (Gare du Midi) | No tags | ||||
| Bus
| Aéroport LYS | Midi | No tags |
Last refresh of the prices: Today at 8:01 PM CEST.
Get from Lyon to Brussels
The journey takes about 12 hours 15 minutes, and with fares starting at just PEN 87, it presents an excellent value for a comfortable ride.
Bus stations and stops in Lyon and Brussels
Stops in Lyon
- B
Perrache
Rue de Esplanade, 69002 Lyon, France - C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - F
Les Charrières
Les Charrières, 69570 Dardilly, France
Stops in Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium - C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
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Frequently asked questions about travelling from Lyon to Brussels by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Lyon to Brussels?
The cheapest bus tickets from Lyon to Brussels start at PEN 87. The average price for this route is around PEN 172. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Lyon to Brussels?
The average bus journey time from Lyon to Brussels is 12h 15m, covering a distance of 572 km. The fastest bus gets you there in 9h 40m and is operated by BlaBlaCar Bus.
Which bus companies service the Lyon to Brussels route?
Several major bus companies operate on this route with 23 buses available per day, including services from FlixBus, BlaBlaCar Bus.
What is the earliest and latest departure time for the bus from Lyon to Brussels?
The earliest bus departs from Lyon to Brussels at 00:10. And the latest bus departs at 23:55.
What are the CO₂ emissions for the bus trip from Lyon to Brussels?
A bus trip from Lyon to Brussels produces an estimated 14.295675 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Lyon to Brussels?
According to Busbud customers, the highest-rated bus company on this route is BlaBlaCar Bus, with an average rating of 3.7 out of 5 stars based on 12910 reviews.
Which bus company has the best Wi-Fi from Lyon to Brussels?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Lyon to Brussels?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Lyon to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is BlaBlaCar Bus, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lyon to Brussels was searched and found on 03 Oct 2026 with a price of PEN 84To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Brussels as early as possible.
You can expect to pay from PEN 84 to PEN 382 for a bus ticket from Lyon to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 84, which is on 2026-10-03.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Lyon to Brussels?
The Bus is the cheapest travel choice for this destination
