Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Lyon Avenue Tony Garnier | Cheapest | ||||
| Bus | Rome Tiburtina Bus Station | Lyon Avenue Tony Garnier | Fastest | ||||
 | Bus | Rome Tiburtina Bus Station | Lyon - Gerland Bus Station | No tags | ||||
 | Bus | Rome Tiburtina Bus Station | Gare routière de Gerland | No tags | ||||
 | Bus | Rome Tiburtina Bus Station | Gare routière de Gerland | No tags |
Last refresh of the prices: Yesterday at 10:46 PM CEST.
Compare 2 ways to travel from Rome to Lyon
Among the sustainable travel choices, the Bus stands out as a good way to reach Lyon. The journey takes about 17 hours 45 minutes and with fares starting at just R 420, it presents an excellent value for a comfortable ride.
| Average price | Average duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average priceR 420 - R 4 322 | Average duration17h 45m | 18kg CO₂e | ||
Train | Average priceR 3 363 - R 6 777 | Average duration8h 42m | 18kg CO₂e |
Where are the popular stops in Rome and Lyon?
Stops in Rome
- A
Rome Ciampino Airport
- B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy - D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Lyon
- A
Lyon Airport
- B
Perrache
Rue de Esplanade, 69002 Lyon, France - C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - F
Les Charrières
Les Charrières, 69570 Dardilly, France
Compare companies
Based on 1074 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the departure location and the ticket access but often complained about the Wi-Fi. RegioJet ticket prices on this trip start at R 2 610
Frequently asked questions about travelling from Rome to Lyon by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Rome to Lyon?
The cheapest bus tickets from Rome to Lyon start at R 420. The average price for this route is around R 1 411. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Rome to Lyon?
The average bus journey time from Rome to Lyon is 17h 45m, covering a distance of 733 km. The fastest bus gets you there in 14h 30m and is operated by Itabus.
Which bus companies service the Rome to Lyon route?
Several major bus companies operate on this route with 12 buses available per day, including services from FlixBus, Itabus, BlaBlaCar Bus, RegioJet.
What is the earliest and latest departure time for the bus from Rome to Lyon?
The earliest bus departs from Rome to Lyon at 00:10. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Rome to Lyon?
A bus trip from Rome to Lyon produces an estimated 18.301175 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Rome to Lyon?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1074 reviews.
Which bus company has the best Wi-Fi from Rome to Lyon?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company offers the most punctual service from Rome to Lyon?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Rome to Lyon?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Lyon was searched and found on 16 Apr 2026 with a price of R 506To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Lyon as early as possible.
You can expect to pay from R 506 to R 3 629 for a bus ticket from Rome to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at R 506, which is on 2026-04-16.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
