Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Columbus (E Mound St) | Knoxville Bus Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 100 E Rich St | Knoxville Bus Station | Fastest | ||||
| Bus | Columbus (E Mound St) | Knoxville Bus Station | No tags |
Last refresh of the prices: Last Thursday at 10:39 AM EDT.
Get from Columbus to Knoxville
The journey takes about 14 hours and with fares starting at just $77, it presents an excellent value for a comfortable ride.
Where are the popular stops in Columbus and Knoxville?
Stops in Columbus
- A
Columbus Bus Station
25 E Rich St, Columbus, OH 43205, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Columbus, OH to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Columbus to Knoxville?
The cheapest bus tickets from Columbus to Knoxville start from $77. The average price for this route is around $121. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Columbus to Knoxville?
The average bus trip duration from Columbus to Knoxville is 14h, covering a distance of 278 miles (447 km). The quickest bus can get you there in 14h and is operated by Greyhound.
Which bus companies service the Columbus to Knoxville route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Columbus to Knoxville?
The earliest bus departs from Columbus to Knoxville at 12:50am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Columbus to Knoxville?
A bus trip from Columbus to Knoxville generates an estimated 11.170875 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Columbus, OH to Knoxville, TN was searched and found on Apr 6, 2026 with a price of $68To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to Knoxville, TN, as early as possible.
You can expect to pay from $68 to $187 for a bus ticket from Columbus, OH to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $68 which is on 2026-04-06.
