Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Price and booking link |
|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus
| Indianapolis Bus Station | UCSD Health La Jolla Station | ||||
Greyhound + FlixBus | Bus
| Indianapolis Bus Station | San Diego (Old Town-FlixBus) | ||||
Greyhound + FlixBus | Bus
| Downtown Transit Center | UCSD Health La Jolla Station | ||||
Greyhound + FlixBus | Bus
| Downtown Transit Center | San Diego (Old Town-FlixBus) | ||||
Greyhound + FlixBus | Bus
| Downtown Transit Center | Greyhound Bus Stop |
Compare 2 ways to go from Indianapolis to San Diego
Among the sustainable travel choices, the Bus stands out as a good way to reach San Diego. The journey takes about 2 days, 5 hours 40 minutes and with fares starting at just $140, it presents an excellent value for a comfortable ride.
Bus stations and stops in Indianapolis and San Diego
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Indianapolis to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Indianapolis to San Diego?
The cheapest bus tickets from Indianapolis to San Diego start from $140. The average price for this route is around $169. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to San Diego?
The average bus trip duration from Indianapolis to San Diego is 2d 5h, covering a distance of 1782 miles (2873 km). The quickest bus can get you there in 2d and is operated by Greyhound.
Which bus companies service the Indianapolis to San Diego route?
Several major bus companies operate on this route with 17 buses available per day.
What is the earliest and latest departure time for the bus from Indianapolis to San Diego?
The earliest bus departs from Indianapolis to San Diego at 3:15am. And the latest bus departs at 11:25pm.
What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?
A bus trip from Indianapolis to San Diego generates an estimated 71.81609999999999 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to San Diego, CA, US was searched and found on Oct 2, 2026 with a price of $136To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, CA, US, as early as possible.
You can expect to pay from $136 to $208 for a bus ticket from Indianapolis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $158 which is on 2026-10-04.
What's the cheapest way to go from Indianapolis to San Diego, CA, US?
The Bus is the cheapest travel choice for this destination
