Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mainz | Brussels North Train Station | CheapestFastest | ||||
| Bus | Mainz | Brussels North Train Station | No tags | ||||
| Bus | Mainz | Brussels Airport BRU (Parking P14) | No tags |
Last refresh of the prices: Today at 12:03 PM CEST.
Compare 2 ways to go from Mainz to Brussels
Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 5 hours 45 minutes and with fares starting at just R$188, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mainz and Brussels?
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz
Stops in Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium - C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Mainz to Brussels by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mainz to Brussels?
The cheapest bus tickets from Mainz to Brussels start from R$188. The average price for this route is around R$291. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mainz to Brussels?
The average bus trip duration from Mainz to Brussels is 5h 45m, covering a distance of 181 miles (291 km). The quickest bus can get you there in 5h 45m and is operated by FlixBus.
Which bus companies service the Mainz to Brussels route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Mainz to Brussels?
The earliest bus departs from Mainz to Brussels at 8:20am. And the latest bus departs at 10:40pm.
What are the CO₂ emissions for the bus trip from Mainz to Brussels?
A bus trip from Mainz to Brussels generates an estimated 7.261375 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mainz to Brussels was searched and found on Jun 3, 2026 with a price of R$183To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mainz to Brussels, as early as possible.
You can expect to pay from R$183 to R$485 for a bus ticket from Mainz to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at R$190 which is on 2026-06-06.
