Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | Indianapolis Bus Station | Cheapest | ||||
| Bus | Gateway Station | Indianapolis Bus Station | Fastest | ||||
| Bus | Gateway Station | Indianapolis Bus Station | No tags |
Last refresh of the prices: Today at 5:10 AM CDT.
Compare 2 ways to go from St. Louis to Indianapolis
Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 4 hours 25 minutes and with fares starting at just COP 127,757, it presents an excellent value for a comfortable ride.
Where are the popular stops in St. Louis and Indianapolis?
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Frequently asked questions about traveling from St. Louis to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from St. Louis to Indianapolis?
The cheapest bus tickets from St. Louis to Indianapolis start from COP 127,757. The average price for this route is around COP 149,559. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from St. Louis to Indianapolis?
The average bus trip duration from St. Louis to Indianapolis is 4h 25m, covering a distance of 230 miles (371 km). The quickest bus can get you there in 4h 25m and is operated by Greyhound.
Which bus companies service the St. Louis to Indianapolis route?
What is the earliest and latest departure time for the bus from St. Louis to Indianapolis?
The earliest bus departs from St. Louis to Indianapolis at 2:00am. And the latest bus departs at 11:45pm.
What are the CO₂ emissions for the bus trip from St. Louis to Indianapolis?
A bus trip from St. Louis to Indianapolis generates an estimated 9.265775 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from St. Louis to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87564 reviews.
Which bus company has the best Wi-Fi from St. Louis to Indianapolis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from St. Louis to Indianapolis?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from St. Louis to Indianapolis?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Indianapolis was searched and found on Jun 16, 2026 with a price of COP 112,605To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Indianapolis, as early as possible.
You can expect to pay from COP 112,605 to COP 334,253 for a bus ticket from St. Louis to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at COP 112,605 which is on 2026-06-16.
What's the cheapest way to go from St. Louis to Indianapolis?
The Bus is the cheapest travel choice for this destination
