Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Price and booking link |
|---|---|---|---|---|---|---|---|
 | Bus
| Rome Tiburtina Bus Station | Terminal Interbus | ||||
| Bus
| Rome Tiburtina Bus Station | Terminal Interbus | ||||
| Bus
| Rome Tiburtina Bus Station | Terminal Interbus | ||||
| Bus
| Rome Anagnina | Terminal Interbus | ||||
| Bus
| Rome Tiburtina Bus Station | Terminal Interbus |
Compare 2 ways to travel from Rome to Syracuse
Among the sustainable travel choices, the Train stands out as a good way to reach Syracuse. The journey takes about 11 hours 11 minutes and with fares starting at just R 1 334, it presents an excellent value for a comfortable ride.
Bus stations and stops in Rome and Syracuse
Stops in Rome
- B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy - D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Syracuse
- A
Fermata dell'autobus Siracusa
Viale Paolo Orsi, 20, 96100 Siracusa SR, Italy - B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Compare bus companies
Based on 16127 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained about the Wi-Fi. FlixBus ticket prices on this trip start at R 520
Frequently asked questions about travelling from Rome to Syracuse by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Rome to Syracuse?
The cheapest bus tickets from Rome to Syracuse start at R 520. The average price for this route is around R 1 225. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Rome to Syracuse?
The average bus journey time from Rome to Syracuse is 22h, covering a distance of 583 km. The fastest bus gets you there in 12h 15m and is operated by FlixBus.
Which bus companies service the Rome to Syracuse route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Rome to Syracuse?
The earliest bus departs from Rome to Syracuse at 15:30. And the latest bus departs at 22:40.
What are the CO₂ emissions for the bus trip from Rome to Syracuse?
A bus trip from Rome to Syracuse produces an estimated 14.57365 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Syracuse was searched and found on 11 Oct 2026 with a price of R 656To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Syracuse as early as possible.
You can expect to pay from R 656 to R 1 399 for a bus ticket from Rome to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at R 656, which is on 2026-10-11.
What's the cheapest way to go from Rome to Syracuse?
The Bus is the cheapest travel choice for this destination
