Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Isernia | Rome Tiburtina Bus Station | CheapestFastest | ||||
| Bus | Isernia | Rome Fiumicino Airport | No tags |
Last refresh of the prices: Today at 12:33 AM CEST.
Compare 2 ways to go from Isernia to Rome
Among the sustainable travel choices, the Train stands out as a good way to reach Rome. The journey takes about 2 hours 25 minutes, and with fares starting at just $30, it presents an excellent value for a comfortable ride.
Where are the popular stops in Isernia and Rome?
Stops in Rome
- ALargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Compare bus companies
Based on 12412 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at $17
Frequently asked questions about travelling from Isernia to Rome by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Isernia to Rome?
The cheapest bus tickets from Isernia to Rome start from $17. The average price for this route is around $52. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Isernia to Rome?
The average bus travel time from Isernia to Rome is 6h 55m, covering a distance of 167 km. The quickest bus can get you there in 2h 10m and is operated by FlixBus.
Which bus companies service the Isernia to Rome route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Isernia to Rome?
The earliest bus departs from Isernia to Rome at 11:25am. And the latest bus departs at 6:05pm.
What are the CO₂ emissions for the bus trip from Isernia to Rome?
A bus trip from Isernia to Rome generates an estimated 4.156775 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Isernia to Rome was searched and found on Apr 4, 2026 with a price of $14To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Isernia to Rome, as early as possible.
You can expect to pay from $14 to $125 for a bus ticket from Isernia to Rome based on the last 2 days. You can expect to find the cheapest price for the trip at $17 which is on 2026-04-10.
