Next available departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Isernia | Termini | Cheapest | |||||
 | Isernia | Rome Tiburtina Bus Station | Fastest | |||||
| Isernia | Termini | No tags | |||||
| Isernia | Rome Fiumicino Airport | No tags | |||||
 | Isernia | Termini | No tags |
Last refresh of the prices: Yesterday at 11:51 PM CEST.
Compare 2 ways to go from Isernia to Rome
Among the sustainable travel choices, the Train stands out as a good way to reach Rome. The journey takes about 2 hours 30 minutes, and with fares starting at just R$95, it presents an excellent value for a comfortable ride.
Bus stations and stops in Isernia and Rome
Stops in Rome
- A
Termini
Piazza dei Cinquecento 1, 00185 Roma RM, Italy - B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy - C
Rome Fiumicino Airport (FCO), Train station
Fiumicino Aeroporto, 00054 Fiumicino RM, Italy - D
Roma S. Pietro
Roma S.Pietro, 00165 Roma RM, Italy - F
Roma Trastevere
Roma Trastevere Railway Station, 00152 Roma RM, Italy
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Frequently asked questions about travelling from Isernia to Rome by bus or train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is a ticket from Isernia to Rome?
The cheapest tickets from Isernia to Rome start at R$72. The average price for this route is around R$188. Busbud recommends booking your tickets in advance for a better chance of getting the lowest possible price.
How long is the ride from Isernia to Rome?
The average trip duration from Isernia to Rome is 4h 37m, covering a distance of 154 km. The quickest vehicle can get you there in 2h 7m and is operated by Trenitalia.
Which companies service the Isernia to Rome route?
Several major companies operate on this route with 3 trips available per day, including services from FlixBus, Trenitalia.
What is the earliest and latest departure time from Isernia to Rome?
The earliest trip from Isernia to Rome departs at 7:08am. And the latest trip departs at 6:15pm.
What are the CO₂ emissions for the trip from Isernia to Rome?
A trip from Isernia to Rome generates an estimated 3.8434375000000003 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best company from Isernia to Rome?
According to Busbud customers, the highest-rated company on this route is Trenitalia, with an average rating of 3.9 out of 5 stars based on 69 reviews.
Which company has the best Wi-Fi from Isernia to Rome?
Based on Busbud reviews, the company FlixBus has the highest Wi‑Fi rating with a score of 2.7.
Which company has the most on-time service from Isernia to Rome?
According to Busbud traveller reviews, the most punctual company on this route is Trenitalia, with a punctuality rating of 4.4 out of 5 stars.
Which company has the cleanest vehicles from Isernia to Rome?
According to Busbud traveller reviews, the company with the cleanest vehicles on this route is Trenitalia, with a cleanliness rating of 4.7 out of 5 stars.
Find the cheapest prices for buses and trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Isernia to Rome was searched and found on Aug 27, 2026 with a price of R$73To save money and make sure you have the best seat, it's a good idea to buy your bus and train tickets from Isernia to Rome, as early as possible.
You can expect to pay between R$73 and R$581 for a bus or train ticket from Isernia to Rome based on the past 2 days. You can expect to find the lowest price for this trip at R$73 on 2026-08-27.
